Northbridge Pharma · Medical Information
Reference MI-2026-0001 · for Dr Daniel Forde · sent 27 October 2026
Dear Dr Daniel Forde,
Thank you for your question. No dose adjustment of Velorin is needed in mild or moderate renal impairment [1]. Velorin has not been studied in severe renal impairment (eGFR below 30 mL/min/1.73 m²) or in patients on dialysis, so no dosing recommendation can be made for these patients [1]. In a pooled pharmacokinetic analysis, velorimab exposure was similar across renal function groups down to an eGFR of 30 [2].
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Medical Information
References
- [1] Velorin (velorimab) Summary of Product Characteristics — SYNTHETIC development label, section 4.2
- [2] Data on file: VEL-PK-POOL-01, pooled population pharmacokinetic analysis (synthetic)
Approved standard response VEL-SRL-001 v1.
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